Sox2: A multitasking networker

Sox2: A multitasking networker

The transcription factor Sox2 is best known as a pluripotency factor in stem and precursor cells and its expression generally correlates with an undifferentiated state. Proposed modes of action include those as classical transcription factor and pre-patterning factor with influence on histone modifications and chromatin structure. Recently, we provided the first detailed analysis of Sox2 expres...

NetWorker Support for OpenVMS Whitepaper

GRASP: A Multitasking Tether

Originally identified as Golgi stacking factors in vitro, the Golgi reassembly stacking protein (GRASP) family has been shown to act as membrane tethers with multiple cellular roles. As an update to previous comprehensive reviews of the GRASP family (Giuliani et al., 2011; Vinke et al., 2011; Jarvela and Linstedt, 2012), we outline here the latest findings concerning their diverse roles. New in...

Melatonin: a multitasking molecule.

Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously distributed and functionally diverse molecule. The mechanisms that control its synthesis within the pineal gland have been well characterized and the retinal and biological clock processes that modulate the circadian production of melatonin in the pineal gland are rapidly being unravelled. A feature that characteriz...

Multitasking behavior

This chapter does not attempt to furnish an overview of multitasking research in every scientific discipline. Rather, we highlight the importance of multitasking in the cognitive and information sciences and the need for further research on multitasking, particularly within the context of information behavior. Why are we interested in multitasking? Why is multitasking an important theoretical a...